Has Baxter Intern'l released a biological weapon?

Events indicative of the end-times which may, or may not, be related to a specific Scripture.

Has Baxter Intern'l released a biological weapon?

Postby OneDay on Mon Nov 02, 2009 10:05 pm

http://theflucase.com/index.php?option= ... id=105?=en

Evidence appears to suggest that Baxter International is responsible for a new deadly outbreak of viral pneumonia in Ukraine.

In February of 2009 Bloomberg reported that Baxter “accidentally” send vaccine material containing both live Avian bird flu and seasonal influenza to multiple laboratories worldwide. A laboratory decided to test the vaccine on it’s ferrets, but the ferrets all unexpectedly died. It must be noted that Baxter has made a “mistake” like this before. Blood products produced by Baxter once containd HIV. Thousands of haemophiliacs died due to this, and many went on to infect their spouses.
continues...
Exalt the Lord our God and worship at His holy mountain, for the Lord our God is holy.
Psalm 99:9
http://www.acwitness.org/psalm83english.html
User avatar
OneDay
 
Posts: 1668
Joined: Mon Feb 12, 2007 9:50 am

Re: Has Baxter Intern'l released a biological weapon?

Postby OneDay on Mon Nov 02, 2009 10:06 pm

http://www.stevequayle.com/News.alert/0 ... eapon.html

The BIG story this morning, economic in nature, is that "Swine Flu Grips Ukraine". It's in the Wall Street Journal, after all, so it must have something to do with economics, right?

And indeed it does: Ukraine is something of a bread basket area to Russia populated by smart, hard-working people. Since independence in late summer 1991, Ukraine has been evolving into the 29th largest economy in the world on a mix of agriculture, aerospace, and manufacturing while being a critical chunk of real estate to the Russians since goods like natural gas from Russia to Europe through its borders.

As of this weekend, 53 people have died of swine flu, some by what's described as bleeding lungs which hark back to the 1918 Spanish Flu and cytokine storming where the body's defensive mechanisms got crazy and attack the host body itself.

Responding to the situation, the government is closing down schools, some businesses, banning large gatherings, and is trying to buy another 700,000 doses of Tamiflu from Roche. A stock to watch?

The thing we probably should watch over the next few days is how the neighboring countries fare. Already Hungary's health minister says the "Ukraine flu epidemic to create emergency in Hungary" as it may also do in Romanian, Moldova, Slovakia, Poland, Belarus, Russia, and anyone pulling into port from he Black Sea or the Sea of Azov.

Now we go into deep background mode on this with an email I received from a particularly well informed reader who expects this will be one for the history books that should be watched closely:
"This story may be the most important of our lifetimes. I'm a retired Ph.D. biochemist FYI. I conjecture that much of the coming troubles the web bot project speaks of may well arise from this new flu variant. I note that the first cases appeared a few days ago, just the length of the incubation period from October 25th.
OK, a Mossad microbiologist warned two months ago that a new deadly flu bug was going to be released into Ukraine in two months. He got the place right, the bug right, and the time right.

The sequence of all 8 pieces of RNA in the virus that caused the "Spanish flu" pandemic of 1918-1919 is public knowledge. A long dead Inuit woman buried in the permafrost was dug up and the virus taken from her body a couple of years ago and the RNA pieces were sequenced. Quite simple to synthesize these 8 pieces with widely available commercial machines and reagents. Then transfect mammalian cells with the RNA genes to obtain the intact, fully functional, virus. Another quite well known technology. Then grow all you want in fertilized chicken eggs or a mammalian immortal cell line. More quite well known technologies.

What scares the sh*t out of me is that the bleeding in the lungs is exactly what killed a lot of folks in the 1918-19 pandemic. See the great book "The Great Influenza: The story of the deadliest pandemic in history? ." People would literally fall dead walking across the street. The bleeding out of the lungs was most likely the result of a "cytokine storm" that so increased the vascular permeability in the air sacks that blood filled the lungs. The reason why the mortality in the 1918-1919 pandemic was concentrated in the 18-25 yo cohort was that they had the most active immune systems.

Now I've NO conjecture as to who may have let this loose or why. But I do know that the technology is widespread to replicate the 1918-1919 virus that killed 2-4 million Americans and about 50 million world wide. And folks only traveled by ship in 1918. And there is NO vaccine for this flu type.

Hopefully we will know in a couple of weeks the sequences of the 8 RNA pieces in the Ukraine virus. I'll bet the farm that it is a replicant of the "Spanish Flu." If so, the odds are totally infinitesimal that this was NOT a deliberate bioweapon release.

I note that long haul truckers will simply go home and park their rigs if this flu reaches the USA. And exactly what reason do we have to suppose that it will be confined to Ukraine? The average city has 3 days of food. Connect the dots... please...............
Exalt the Lord our God and worship at His holy mountain, for the Lord our God is holy.
Psalm 99:9
http://www.acwitness.org/psalm83english.html
User avatar
OneDay
 
Posts: 1668
Joined: Mon Feb 12, 2007 9:50 am

Re: Has Baxter Intern'l released a biological weapon?

Postby OneDay on Mon Nov 02, 2009 10:41 pm

http://www.who.int/csr/don/2009_11_01/en/index.html

Pandemic (H1N1) 2009, Ukraine

On 28 October 2009, the Ministry of Health of the Ukraine informed WHO, through its Country Office in Ukraine, about an unusually high level of activity of acute respiratory illness in the western part of the country, associated with an increased number of hospital admissions and fatalities.

On 30 October 2009, the Ministry of Health of the Ukraine announced the confirmation of pandemic (H1N1) 2009 virus infection by RT-PCR in eleven out of 30 samples obtained from patients presenting with acute respiratory illness in two of the most affected regions. Tests were performed in two laboratories in Kyiv, including the National Influenza Centre. Confirmatory tests will be performed at one of the WHO Collaborating Centres for Influenza.

The situation is quickly changing with increasingly high levels of acute respiratory illness (ARI)/Influenza-like-illness (ILI) activity being observed in Ternopil, Lviv, Ivano-Frankivsk, and Chernivtsi regions. The higher levels of transmission in these regions corresponds to an increased number of hospital admissions and fatalities associated with severe manifestations of acute respiratory illness.
continues...
Exalt the Lord our God and worship at His holy mountain, for the Lord our God is holy.
Psalm 99:9
http://www.acwitness.org/psalm83english.html
User avatar
OneDay
 
Posts: 1668
Joined: Mon Feb 12, 2007 9:50 am

Re: Has Baxter Intern'l released a biological weapon?

Postby joyfulchild on Tue Nov 03, 2009 2:02 am

im so there

I HAVE BEEN WATCHING THIS TOO VERY CLOSELY. I HOPE THIS THREAD DOESNT GET LOCKED FOLKS GO TO GOOGLE UKRAINE AND SEE THIS IS BEING COVERED OK NOW .


http://www.who.int/csr/don/2009_11_01/en/index.html


Pandemic (H1N1) 2009, Ukraine
On 28 October 2009, the Ministry of Health of the Ukraine informed WHO, through its Country Office in Ukraine, about an unusually high level of activity of acute respiratory illness in the western part of the country, associated with an increased number of hospital admissions and fatalities.

On 30 October 2009, the Ministry of Health of the Ukraine announced the confirmation of pandemic (H1N1) 2009 virus infection by........MORE AT LINK

http://mignews.com.ua/en/articles/376537.html
joyfulchild
 
Posts: 1668
Joined: Tue Sep 19, 2006 12:17 am
Location: around


Re: Has Baxter Intern'l released a biological weapon?

Postby learningeachday on Tue Nov 03, 2009 5:54 am

I've only had time to read the first article, but it's all soooooo weird and creepy! :eek: Hard not to watch this one... :(

:shock: :shock: :shock: :shock: :shock: :shock: :shock: :scared2:
learningeachday
 
Posts: 479
Joined: Sat Aug 29, 2009 8:20 pm
Location: Illinois

Re: Has Baxter Intern'l released a biological weapon?

Postby OneDay on Tue Nov 03, 2009 10:26 am

Plague: A New Thriller of the Coming Pandemic
http://www.foreignpolicy.com/articles/2 ... g_pandemic

Sometimes fiction can do more to change public opinion than nonfiction. It took Upton Sinclair's 1906 novel, The Jungle, to awaken the public to the dangers of sausage and the meat-packing industry in general. Another example, if I can be so presumptuous, is my 1977 novel Coma, which opened readers' eyes to the dubious side of the medical profession after years of misleadingly warm and fuzzy treatment of doctors and hospitals in novels, movies, and TV series. Today, there is a crying need for a new such socially conscious novel to shake up the complacent public about the high risk of an imminent, serious pandemic. And I don't mean the much-publicized swine flu. While the world media has obsessed, and rightfully so, about this fast-spreading illness, I'm worried about the next crisis, something much deadlier and much more catastrophic, indeed the kind of crisis most people wrongly believe could not happen in this day and age. If I were the author, this urgently needed novel would have to be called Plague.
continues...
Exalt the Lord our God and worship at His holy mountain, for the Lord our God is holy.
Psalm 99:9
http://www.acwitness.org/psalm83english.html
User avatar
OneDay
 
Posts: 1668
Joined: Mon Feb 12, 2007 9:50 am

Re: Has Baxter Intern'l released a biological weapon?

Postby Mttw633 on Tue Nov 03, 2009 11:06 am

prayerfully consider this:
1. Joseph Moshe an israeli microbiologist, went on a Dr True Ott's radio broadcast telling the host he has proof that baxter did in fact do the unthinkable and he was going to release evidence to the fact to the states attorney. The next day as he was trying to reach the Israeli consulate office he was swarmed by the secret service, armored vehicles, and a robot, the media spun it saying that the person inside made a threat against the white house...it can be seen on youtube. This all happened in August of this year.

2. I received an email about a prophetic vision a woman (Rosie Lovejoy) had in 2003, and here's a portion:



Next an image appeared that replaced the peaceful scene. The face of someone evil appeared covered in a gas mask with a tube attached [i]. The color of the gear was a steely gray. Hatred emanated from behind the dark glass eyes of the mask. [me here; reminds me of the picture in the denver airport, the man w/ the gas mask?]The feeling of evil was so great I nearly sunk to the floor in horror and my stomach became nauseous. There was a stench of vileness about the person within the protective gear.[ii]



Next I saw a hypodermic needle filled with some sort of vaccine. I saw a hand squirt a drop or two of the vaccine into the air and then the needle was turned and inserted into a waiting shoulder. [iii]



Then the Lion appeared again, in an upright sitting position. Beside Him a gorgeous Red flag appeared. It was large with gold letters on it-Yod He Vod Hey – the Hebrew name for GOD (YAHWEH). The flag was fringed with gold, and gold tassels fluttered in the breeze. It was a very regal, very exquisite, very expensive looking flag.



Soon I saw a number of sheep appear behind the Lion, and He rose to His feet. The sheep came and began to make row after row of lines behind the Lion, each line being a bit longer than the one before it. Soon it stretched out and from the front looked like a solid V, with the Lion standing at the point of the V. The sheep looked quite dumb, and very content.



The Lion spoke to me:



”Did you think I would leave my humble ones unprotected during the times to come?”
Mttw633
 
Posts: 2931
Joined: Mon Mar 06, 2006 9:49 am

Re: Has Baxter Intern'l released a biological weapon?

Postby joyfulchild on Tue Nov 03, 2009 12:19 pm

HEY ONE DAY! :grin:


Another example, if I can be so presumptuous, is my 1977 novel Coma, which opened readers' eyes to the dubious side of the medical profession after years of misleadingly warm and fuzzy treatment of doctors and hospitals in novels, movies, and TV series


NOT TO DERAIL THREAD BUT ARE YOU ROBIN COOK? :grin:
joyfulchild
 
Posts: 1668
Joined: Tue Sep 19, 2006 12:17 am
Location: around

Re: Has Baxter Intern'l released a biological weapon?

Postby GodsStudent on Tue Nov 03, 2009 12:29 pm

:a3: To all of the ladies who have outdone themselves putting this thread together, a heart felt THANK YOU! Please know that your efforts are appreciated!

To the entire christian population, I am willing to go on record with this one.....I did not receive a dream or a vision, but I have a knowing in my spirit...We have a scripture that is constantly with me and has been for some time now. Luke 21: 36 Watch ye therefore, and pray always, that ye may be accounted worthy to escape all these things that shall come to pass, and to stand before the Son of man.

Brothers and sisters, I emplore you, whomever you are, and whereever you are, please pray ceaselessly. Please pray as advised in the above scripture. This is the answer to these things that devils of false gods are putting out into our world. It is so important for us to have the appropriate response and word for others where these things are concerned. I am fully prepared to stand and proclaim at 100% that the answer for the saints is here in my post, and there is no other answer. We are able to be wise as serpents and gentle as doves. We need not get all charged up about these headlines, but we must draw close to the Lord and pray that He will guide us around these events that are unfolding, this biological travesty among others, included. Please heed the good disciple's warning and have faith. Please share with others that this is the answer.

Daniel 11: 32 And such as do wickedly against the covenant shall he corrupt by flatteries: but the people that do know their God shall be strong, and do [exploits].

This is one of our exploits, brothers and sisters. I say the Lord has shown me this and I am not afraid to pass it on. Be strong, not fearful....have faith and pray to escape these things and lead others to the same.

:armor:
GodsStudent
Supporting Member
 
Posts: 4177
Joined: Sun Mar 16, 2008 10:36 pm

Re: Has Baxter Intern'l released a biological weapon?

Postby joyfulchild on Tue Nov 03, 2009 12:38 pm

2. I received an email about a prophetic vision a woman (Rosie Lovejoy) had in 2003, and here's a portion

HEY MTTW23 CAN I POSSIBLY SEE THIS VISION?FEEL FREE TO PM ME?
joyfulchild
 
Posts: 1668
Joined: Tue Sep 19, 2006 12:17 am
Location: around

Re: Has Baxter Intern'l released a biological weapon?

Postby Mttw633 on Wed Nov 04, 2009 5:46 pm

This is really good, she's a benedictine nun who before becoming a nun she was a internal medicine physician in Spain. She explains really well what's going on w/ the swine flu, she says it's less harmful than the regular flu. I've only watched the first one, but there's 5 more.

http://www.youtube.com/watch?v=A0JqQyl0 ... r_embedded
Mttw633
 
Posts: 2931
Joined: Mon Mar 06, 2006 9:49 am

Re: Has Baxter Intern'l released a biological weapon?

Postby Mttw633 on Fri Nov 06, 2009 12:17 pm

I don't watch the tv news, but I consider drudgereport to be the most efficient at getting the latest news the fastest- why aren't they discussing the flu/sickness spreading in the Ukraine? That is the country Joseph Moshe said it would be the target of a bioweapon. Are we now seeing this to be true? They haven't received the swine flu vaccine yet as I've read this morning, don't know that to be true, but this has a deadly twist, the hemoraging of the lungs.
http://health.yahoo.com/news/afp/health ... 64007.html

Is any other msm reporting this?
Mttw633
 
Posts: 2931
Joined: Mon Mar 06, 2006 9:49 am

Re: Has Baxter Intern'l released a biological weapon?

Postby Swayde on Fri Nov 06, 2009 12:34 pm

Mttw633 wrote:I don't watch the tv news, but I consider drudgereport to be the most efficient at getting the latest news the fastest- why aren't they discussing the flu/sickness spreading in the Ukraine? That is the country Joseph Moshe said it would be the target of a bioweapon. Are we now seeing this to be true? They haven't received the swine flu vaccine yet as I've read this morning, don't know that to be true, but this has a deadly twist, the hemoraging of the lungs.
http://health.yahoo.com/news/afp/health ... 64007.html

Is any other msm reporting this?



I can't find much about it in the MSM at all. It's shocking to me with all the hype of the swine flu and how big a deal they made every time someone new was diagnosed or died. It was ridiculous. Now a case actually justifies letting people know, I mean 600,000 possibly infected and 95ish dead is significant, and they are silent. It's mind boggling.

My husband's theory is political. Possibly they don't want us sending stuff to Ukraine to aid them for whatever reason and that's why we're not told about it here.
~Barbara
User avatar
Swayde
 
Posts: 2755
Joined: Thu Mar 09, 2006 6:53 am
Location: Florida

Re: Has Baxter Intern'l released a biological weapon?

Postby Mttw633 on Sat Nov 07, 2009 4:50 pm

http://www.president.gov.ua/en/news/15609.html

portion of President of Ukraine to the public:

I address you in performance of my constitutional duty under the Article 106 of the Basic Law of the state.

The reason is the emergency epidemic situation in the country.

Infections of viral origin, including the A/H1N1 flu, are rapidly spreading across Ukraine.

The emergency is evident in the scale of the epidemic: the speed and the geography of its spreading, rapid progress of the illness and the exceptional number of deaths.

People are dying. The epidemic is killing doctors. This is absolutely unprecedented and inconceivable in the XXI century.

All the limits have been exceeded - even those under the Constitution that determine my actions as the President.

Therefore I am motivated by the most important: the security of your life and your health.

Therefore I give clear and frank assessment of the situation. And you should know that.

We have special risk factors that aggravate the epidemic in Ukraine.

The conclusions of the National Security and Defense Council of Ukraine, my numerous consultations with national and international experts show that.

First. Unlike similar epidemics in other countries, three pathogens of viral infections came to Ukraine at the same time: two of them are seasonal flu and the third is the A/H1N1.

According to virologists, such a combination of infections due to mutation may produce a new, even more aggressive virus.
Mttw633
 
Posts: 2931
Joined: Mon Mar 06, 2006 9:49 am

Re: Has Baxter Intern'l released a biological weapon?

Postby joyfulchild on Sat Nov 07, 2009 8:15 pm

UKRAINE UPDATE-DIFFICULT TO GET ACCRATE INFO AS THERE ARE MANY CONFLICTING REPORTS

http://www.who.int/mediacentre/news/rel ... index.html



Reducing child deaths from pneumonia

US$ 39 billion needed to prevent and control the world's leading killer of young children

2 NOVEMBER 2009 | GENEVA | NEW YORK -- A comprehensive action plan that can save up to 5.3 million children from dying of pneumonia by 2015 is being launched today by the WHO and United Nations Children's Fund (UNICEF).

.....MORE AT LINK

The GAPP has a three-pronged vision:

1. Protecting every child by providing an environment where they are at low risk of pneumonia (with exclusive breastfeeding for six months, adequate nutrition, preventing low-birth-weight, reducing indoor air pollution, and increasing hand washing);

2. Preventing children from becoming ill with pneumonia (with vaccination against its causes: measles, pertussis, Streptococcus pneumoniae and Haemophilus influenzae b, as well as preventing and treating HIV in children, and providing zinc for children with diarrhoea);

3. Treating children who become ill with pneumonia with the right care and antibiotics (in communities, health centres and hospitals).

The cost of implementing the GAPP by scaling up the recommended measures in the 68 high burden countries is estimated at US$ 39 billion for 2010-2015. The costs are expected to double over the six-year period, rising from an annual need of US$ 3.8 billion in 2010 to US$ 8.0 billion by 2015.

Specific targets and goals to be reached by 2015 under the GAPP strategy are to expand coverage of all relevant vaccines and exclusive breastfeeding rates to 90%, and raise the level of access to appropriate pneumonia case management to 90%. This will lead to a reduction in child pneumonia deaths by 65% and cutting the number of severe pneumonia cases in children by 25%, compared to 2000 levels.

For further information, please contact:


http://www.theflucase.com/index.php?opt ... 64&lang=en
joyfulchild
 
Posts: 1668
Joined: Tue Sep 19, 2006 12:17 am
Location: around

Re: Has Baxter Intern'l released a biological weapon?

Postby joyfulchild on Sat Nov 07, 2009 8:23 pm

PNEUMONIC PLAGUE DRILL TO BE HELD NOW IN ILLINOIS
http://current.com/items/91393722_pneum ... linois.htm

In Lake in the Hills, Illinois, police will conduct a drill to combat a fictitious pneumonic plague on Saturday. “The Lake in the Hills Police Department is carrying out the test as part of a grant from the McHenry County Department of Health for its emergency health plan. In case of a biological terrorist attack or widespread disease outbreak, the site would be able get medicine to the community, Lake in the Hills Chief of Patrol Services David Brey said,” reports the Northwest Herald. Brey said officials picked pneumonic plague for the scenario “so it would have nothing to do with the swine flu.”

STRANGE COINCEDENCE?
joyfulchild
 
Posts: 1668
Joined: Tue Sep 19, 2006 12:17 am
Location: around

Re: Has Baxter Intern'l released a biological weapon?

Postby joyfulchild on Sat Nov 07, 2009 8:37 pm

http://www.avianflutalk.com/forum_posts ... 5832&PN=11


KIEV, Nov. 5 – Prime Minister Yulia Tymoshenko on Thursday changed her stance towards accepting vaccination after the World Health Organization warned that two more strains of flu, including the bird flu, may strike Ukraine.

The change comes three weeks after the start of a deadly swine flu epidemic in Ukraine that is believed to have killed about 100 people so far and infected hundreds of thousands.

“We cannot relax even for a moment because the World Health Organization predicts two more waves of flu, including the bird flu :eek: MEL WHAT IS THIS THREATS?
, are expected in Ukraine,” Tymoshenko said at a meeting with local administration in Chernivtsi.

“There is no alternative to vaccination,” Tymoshenko said. “The entire world is going this way, but we have to analyze the tactic and approach towards the vaccination. When the country is going through difficult times, like today’s epidemic, we have to think how to develop a strategy towards protecting the people.”

The meeting comes a day after Tymoshenko admitted she was not vaccinated and that she prefers “like all other people” to rely on garlic, onion and lemon as a way of preventing the flu.

Her comment, made in Ivano-Frankivsk, the epicenter of the swine flu, was extremely controversial and misleading as the vaccination is the only known way of preventing the flu.

The rate of vaccination in Ukraine is extremely low – at about 58% - as many people believe vaccination was not effective or even dangerous. This perhaps explains why Ukraine – unlike other countries in the region - is especially hard hit by the flu.

Experts say the rate of vaccination must increase to at least 90% in order to prevent the spread of viruses causing flu.

President Viktor Yushchenko, in a televised address to the nation on Wednesday, urged the people to get vaccinations as soon as possible after consulting their doctors.

Ukraine has been battling the outbreak of the swine flu for the past three weeks, with measuring mainly including shutting down schools and banning pubic gatherings.

The World Health Organization, which sent a team to Ukraine to investigate the illnesses, said it has reasons to believe the outbreak may be caused by the swine flu, also known as (A)H1N1.

Separately, the European Union will send its own team to Ukraine with experts expected to arrive on Friday on mission to check on the spread of the epidemic and to provide recommendations.

“The vaccination is needed, it will be conducted against both, the seasonal flu and the Californian flu,” Oleksandr Turchynov, the first deputy prime minister, said Thursday. Officials often refer to the swine flu in Ukraine as the Californian flu.

“Due to political speculations, a black zone around the vaccinations has been created in Ukraine,” Turchynov said. “This problem was shifted from expert to political sphere. The number of people getting vaccination has dropped considerably.”

Meanwhile, Tymoshenko said the number of new cases involving flu-like illnesses has slowed down after three weeks of rapid growth, perhaps suggesting the epidemic may be leveling off.

The pattern of previous seasonal flu epidemics suggests that the spread of the disease will stop and will be subsiding over the next three weeks.

“I think that we have reached more or less clear stability,” Tymoshenko said. “Now there will be three weeks that the epidemic will gradually subside and we will see the situation returning back to normal.” (tl/ez)




DO YOU SEE WHATS HAPPENING HERE
joyfulchild
 
Posts: 1668
Joined: Tue Sep 19, 2006 12:17 am
Location: around

Re: Has Baxter Intern'l released a biological weapon?

Postby Mttw633 on Sun Nov 08, 2009 10:32 am

http://www.recombinomics.com/N.....q_NOT.html

Withheld Ukraine Sequences Raise Pandemic Concerns
Recombinomics Commentary 02:30
November 7, 2009

Right now we know that many clinical specimens and viruses have been sent to one of the WHO collaborating centres for further study. We don’t know the results of those studies, and it will probably take a couple of days for the full analysis of those viruses to be available. But in the meantime, what we do not have is any evidence of viruses there or anywhere else as showing any big mutations. I raise this point because I have seen in some media reports that there are reports that WHO or other groups are saying that there are mutations and I want to point out that these are rumours and factually, untrue.

The above comments from Keiji Kukuda offer some general comments on the Ukrainian H1N1 sequences at Mill Hill in London. He specifically says WHO doesn’t see any “big” mutations in the samples being sequenced, which would refer to reassortment or Tamiflu resistance. However, the changes seen in Ukraine do not require “big” mutations. Small mutations, such as SNP can have profound effects for a virus like pandemic H1N1.

That virus normally circulates in swine, and has recently jumped to humans. It already has many characteristics with the 1918 pandemic strain. Both are swine H1N1 that jumped to humans. Such species jumpers can increase efficiencies with small changes. One good example is position 627 in the PB2 gene. That position comes in two forms. When there is glutamic acid (E) at that position, the PB2 enzyme copies the viral genetic material most efficiently at 41 C, the body temperature of a bird. However, if that position has a lysine (K), the enzyme is most active at 33 C, the temperature of a human nose in the winter. The swine H1N1 has an E, which may be why it goes well in lung, which is 37 C and closer to the optimal replication temperature of 41C. However, a single change that produced the most efficient replication at 37C would lead to even higher levels in the lungs, which could lead to frequent cytokine storms, like those in 1918, instead of the less frequent level seen in Ukraine.

However, the rapid spread of H1N1 in Ukraine (see map), coupled with the high frequency of hemorrhagic pneumonia raise concerns that a small change is leading to a more virulent virus. Similarly, the rapid spread of the virus could also be affected by a small change in another gene, such as HA, which controls entry of the virus to cells and influences tissue tropism.

Mill Hill has acknowledged that they have at least 15 H1N1 positive samples from Ukraine, which would identify a Ukranian specific change. The delay in the announcement of sequence results raises concerns that such changes have been detected, and such changes are undergoing further analysis.

The number of cases in Ukraine continues to expand. The number of patients with H1N1 symptoms is now approaching 1 million. Cases have been increasing at almost 200,000 per day, so it is likely that tomorrow’s report will have over 1 million cases. This rapid spread increases concern that the 15 sequences at Mill Hill contain one or more of these small changes, which has led to a delay in the announcement of sequence results.

More detail on the sequences at Mill Hill is overdue. The rapid spread of H1N1 in Ukraine demands rapid sequence results. Continued delay will only increase concerns.
Mttw633
 
Posts: 2931
Joined: Mon Mar 06, 2006 9:49 am


Return to SIGNS

Who is online

Users browsing this forum: MSN [Bot] and 0 guests